The Science Behind CBD Part 4

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The Science Behind CBD Part 4

What’s the best way to take hemp oil with CBD?

  Reduced CBD (Paste) can be used for ingestion and topical, but this is not the preferred method for most is has it’s place in the market. Commonly, the CBD oil is mixed with a carrier oil, such as hemp oil or coconut oil, which is adjusted to a  specific concentration of CBD. The strong distinctive taste of CBD  comes from the terpenes and not the cannabinoids themselves.This taste is a lot of times masked with chocolate, mint, or other flavorings (natural being the best!). CBD oil or tincture usually comes in a small bottle (30ml-60ml) with a dropper to administer the CBD oil and help monitor ones dosage by counting of drops.

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  The best way to take  a CBD oil mixed with a carrier oil no matter what strength, is to place the recommended number of drops or dropperfuls under your tongue for 15 seconds to access the sublingual gland present in all of our mouths. This allows the CBD to be absorbed directly into the bloodstream (called sublingual administration) for the quickest acting effects from a CBD oil.

Another method is to take a few drops or dropperfuls orally, swish the liquid around in your mouth, and then swallow it. With this method, CBD’s chemical components are absorbed through mucous membranes of the mouth and intestinal tract directly into the bloodstream.

CBD oil mixed with a carrier oil can also be taken as soft-gel capsules to avoid any taste, but absorption is only through the intestinal tract. This decreases the oil’s potential benefits, because some of the chemical components may be broken down by digestion before being absorbed.

What’s the correct dose of CBD?

The average dose range is 10-50 mg of CBD, one to three times per day, though much higher doses of 100-200 mg (sometimes required to control pain) are equally well tolerated. Some people will notice benefit at the lower end of the dose range, but most people will need 15-30 mg to notice any effects. Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky.

If you’re taking the oil in liquid form, one dropperful of a low concentration product (100 mg CBD per fluid ounce) will provide about 3 mg of CBD per dropperful — not enough to notice any significant effects. A dropperful of the medium grade product (500 mg of CBD per fluid ounce) will deliver about 15 mg of CBD — a good starting dose. And a dropperful of a high concentration product (1500 mg CBD per fluid ounce) will provide about 50 mg of CBD per dropperful.

 

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CBD oil is also available as soft gel capsules. With these, the mg quantity of CBD should be designated per capsule. Because some of the chemical compounds in capsules are lost during digestion, you may find you need to take a little more to experience similar benefits.

As with any medicinal herb, start at a low dose and gradually build up to a higher dose as you get used to the effects of the substance. Most people notice benefits almost immediately, but some experts suggest that full benefit does not occur until after a couple of weeks of consecutive use.

What’s the difference between CBD isolate and full-spectrum CBD oil?

A lot. CBD isolate (which is CBD alone) acts very differently in the body than a full spectrum of hemp chemical components. Here are some quick definitions:

• CBD isolate is purified cannabidiol (CBD) without any other chemical components of hemp. Usually purity is a good thing, but in this case, purified CBD is missing all of the other beneficial compounds the hemp plant has to offer.
• Full-spectrum CBD oil contains cannabidiol, plus the full spectrum of other components of the whole plant, including trace amounts of THC (at less than 0.3%), other cannabinoids, and terpenes.
• Broad-spectrum CBD oil is full-spectrum CBD with the THC removed. It’s not as effective as full-spectrum CBD oil with trace THC.

The cannabis plant naturally generates cannabinoids, terpenes, and other chemical compounds to serve different functions in the plant. These functions include regulatory properties, potent antioxidants, and protection from microbes and insects. Any creature that consumes the chemicals from the plant gains these same benefits.

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You can think of the full spectrum of all the chemical compounds found in cannabis as the “language” of the plant. It’s not one chemical, but all the chemicals combined working together that cause a response (again, the entourage effect). When you consume CBD oil, you gain the benefits of all those chemical substances in natural synergy. For that reason, you get full benefit at a dose range of 25-50 mg.

CBD isolate is limited to that single chemical messenger. The synergy provided by the full spectrum of chemicals in CBD oil is lost. This is likely why clinical studies using purified CBD require very high doses, in the range of 750-1500 mg of CBD several times daily, to see a benefit.

When CBD is formally legalized at the national level, prescription drugs providing high doses of purified CBD will become available (several are already in the pipeline). CBD drugs will likely be very costly, require very high doses of CBD isolate, and will likely not provide the same benefits as full-spectrum CBD oil.